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Microfluidic Manufacturing

We use several microfluidic methods for the production of monodisperse droplets and particles with high level of control over size, shape, composition and surface chemistry for energy, food and healthcare applications.

Planar (2D) Glass/PDMS Devices
Dolomite_2D_FFJ_chip.png
Single_Psi_Junct.png

Planar devices can be made out of glass/silicon via etching processes or a polymer (like PDMS and NOA81) via soft- and photo-lithography techniques. We design and produce our bespoke polymer devices by using a microfabrication station for soft- and photo-lithography. We use such devices for droplet/particle fabrication, manipulation and processing.

For instance, we developed a microfluidic platform for the synthesis, characterisation and manipulation of ultralow interfacial tension oil-in-water droplet. The platform consisted of a glass (Dolomite) flow focusing junction device (see top figure) for the production of the droplets and a downstream PDMS device for the characterisation and optical manipulation of the droplets. 

We also developed single Psi-junction devices (see middle figure) for the synthesis of liposomes (see bottom figure) and the solute-driven manipulation of particles.

References

G. Bolognesi et al. (2015) Microfluidic generation of monodisperse ultra-low interfacial tension oil droplets in water. RSC advances, 5, 8114-8121.

N. Singh et al. (2022) Composite Norland Optical Adhesive (NOA)/silicon flow focusing devices for colloidal particle manipulation and synthesis. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 652,129808.

NOA-81_Liposome_Synthesis.png

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